Timeline Simulation in the Construction Process

From Timeline Simulation to user Comfort Analysis, Heat Transfer, Fire and Smoke Simulations, to Acoustic
Performance, BIM data exchange can be used to inform stakeholders about the overall project performance.
What are the state-of-the-art applications being utilized for this purpose? Just like analysis, can simulation
leverage the infinite potential of cloud computing? Can simulation be used to optimize building performance as
well as the safety of occupants?