In NARRATIVE form, describe the plan for the hypothesis-driven review to be conducted. Include the following information in your description:
1) Background and rationale. Provide a brief introduction to the problem, its significance, and why you chose this topic. In your preliminary assessment of your research question and hypothesis, you should determine the feasibility of your proposal.
Hematopoietic stem cell transplant is one of the only curative therapy for sickle cell disease (SCD). It has its limitation with HLA matching. Therefore, HLA matching sibling donor is accounted the most in this transplant in SCD. Most of the transplants in children have a good prognosis with future complications such as growth inhibition, gonadal hypofunction, and some of them lead to sterility as well. However, unrelated adult’s role is transplantation is unclear. Most of the transplant patients suffer from graph vs. host disease (GVHD) adds into future complications. Quality and quantity of their survival assessed.
2) Research question. State the question that you are going to investigate.
HLA identical transplant is only curative therapy for Sickle cell disease, what is the life expectancy in transplanted patients compared to patients who procced without transplantation?
3) Hypothesis. State your assumption about the relationship of the variables.
hematopoetic stem cell transplantation is a ideal choice, but accessibility of treatment and future complication with transplantation should be assessed.