The issue of employee safety was amplified by COVID-19 as organizations redesigned care delivery spaces and protocols on the fly to protect health care workers and patients. These efforts will broaden as health systems ramp up testing of patients and employees, remote working and virtual care services. Organizations need to keep a pulse on staff burnout, continually looking for ways to make their jobs more sustainable and expanding access to mental health services. And also payer shift was seen in 2021. Employers are experiencing difficulty in funding their current plans and considering shifts in plan design or reduction of benefits. They will increasingly look to partner with provider and payer organizations to manage costs and the health of their teams. Providers will continue to collaborate with payers to advance low-cost, high-quality care, with a focus on growing ambulatory and virtual care services to adapt to patients’ evolving needs. Payers will shape their investments and plan designs to drive high-quality virtual care and increasingly recognize home as a path for care, while managing their networks for high acuity and chronic care pathways.